Lowbright
Derek Kirk Kim. The man needs no introduction. Same Difference is one of the best written graphic novels EVER!!! The book contains some of the best comics dialogue since "Hate".

Leisuretown
I recommend Tristan Farnan's comic about working at the San Francisco Public Library.

Demian5
The most dazzling web comic ever!

Narbonic
Shaenon Garrity's has got to be the most determined cartoonist I've ever met. Not only does she keep up with the greuling schedule of creating a daily strip. But the strip doesn't even appear in the paper! It runs exclusively on her website. This does not reflect well on her mental state. As an added bonus, the strip is really good.

Davidgaddis.com
Check out his comic "Piercing" online. Easily the prettiest comic on the web, not unlike the author himself. Full disclosure: David Gaddis is my roommate!

Niemworks.com
Niem is the talented cartoonist behind "Yes and Notebook" which you can read on his site. He also builds the Acme Novelty Library paper models.

Signalstation
This comic is really wierd.